The Arany Lab, Department of Oral Biology and Biomedical Engineering, University at Buffalo and OptiMed Technology, Inc. has developed a novel approach to improve oral-dental health that is currently a 14 billion dollar market. A novel formulation with polymeric microspheres has been developed to address a condition termed Drug-Induced Gingival Overgrowth (DIGO) that is caused by side-effects of commonly used medications for high blood pressure, convulsions, and organ transplants. This disease affects over 20 million patients in the U.S currently. The commercialization of these formulations is currently underway.